General (including evidence of efficacy) Background Activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role in development and progression of heart failure (HF). Angiotensin II, one of the most potent neurohormones in this system, is known to cause vasoconstriction, sodium retention, cardiac hypertrophy, cell death, endothelial dysfunction and other detrimental cardiovascular effects. Most of…
- Loading...
