Bleeding Risk Scores Compared in Atrial Fibrillation

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The ORBIT score showed the best discrimination for major, life-threatening, and intracranial bleeding.
The ORBIT score showed the best discrimination for major, life-threatening, and intracranial bleeding.

HealthDay News — Four contemporary clinical bleeding risk scores are able to identify atrial fibrillation (AF) patients at risk for major bleeding and life-threatening bleeding, according to a study published online in the Journal of Internal Medicine.

Marco Proietti, MD, from the Sapienza University of Rome, and colleagues compared the performance of contemporary clinical bleeding risk scores (HAS-BLED, ORBIT, ATRIA, and HEMORR2HAGES) in 18,113 patients with AF randomized to dabigatran (110 or 150 mg) or warfarin in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial.

The researchers found that over a median follow-up of 2.0 years, there were 1182 major bleeding events. For all the 4 risk scores, high-risk subgroups had higher risk of major bleeding (all P <.001). 

The ORBIT score showed the best discrimination for major, life-threatening, and intracranial bleeding, which were significantly better than for the HAS-BLED score (all P <.05). For dabigatran 150 mg twice a day vs warfarin, there were significant treatment interactions between the bleeding scores and the risk of major bleeding with the ORBIT (P =.0019), ATRIA (P <.001), and HEMORR2HAGES (P <.001) scores, while the HAS-BLED score showed a non-significant trend for interaction (P =.0607).

"Among the current clinical bleeding risk scores, the ORBIT score demonstrated the best discrimination and calibration," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Boehringer Ingelheim, which funded the RE-LY trial.

Reference

Proietti M, Hijazi Z, Andersson U, et al. Comparison of bleeding risk scores in patients with atrial fibrillation: insights from the RE-LY trial [published online October 16, 2016]. J Intern Med. doi:10.1111/joim.12702

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