Substance Use May Increase Mortality in Younger Patients With MI

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Use of cocaine and/or marijuana correlated with significantly higher cardiovascular and all-cause mortality in patients with MI.
Use of cocaine and/or marijuana correlated with significantly higher cardiovascular and all-cause mortality in patients with MI.

HealthDay News — Cocaine and/or marijuana use was present in about 10% of patients with myocardial infarction (MI) ≤50 years old and was associated with increased mortality, according to a study published online in the Journal of the American College of Cardiology. The research was published to coincide with the annual meeting of the American College of Cardiology, held from March 10 to 12 in Orlando, Florida.

Ersilia M. DeFilippis, MD, from Brigham and Women's Hospital in Boston, and colleagues examined the prevalence of cocaine and marijuana use in adults with their first MI at ≤50 years. Records of patients presenting with a Type 1 MI from 2000 to 2016 were reviewed. Data were included for 2097 patients with Type 1 MI who were followed for a median of 11.2 years.

Cocaine (4.7%) and/or marijuana (6.0%) was present in 10.7% of patients overall. The rates of diabetes and hyperlipidemia were significantly lower in individuals with substance use, while tobacco use was significantly more likely. After adjustment for baseline covariates, there was a correlation for use of cocaine and/or marijuana with significantly higher cardiovascular and all-cause mortality (hazard ratios, 2.22 and 1.99, respectively).

"These findings reinforce current recommendations for substance use screening among young adults with an MI, and highlight the need for counseling to prevent future adverse events," the authors wrote.

Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.

Reference

DeFilippis EM, Singh A, Divakaran S, et al. Cocaine and marijuana use among young adults presenting with myocardial infarction: the Partners YOUNG-MI registry [published March 10, 2018]. J Am Coll Card. doi:10.1016/j.jacc.2018.02.047

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