Comparative Recurrence Risk of Isolated SVT, Proximal DVT Post-AC Discontinuation
Incidence risk is lower with first superficial vein thrombosis after stopping anticoagulant therapy compared to those with proximal deep vein thrombosis.
HealthDay News — Patients with isolated superficial vein thrombosis (iSVT) have a similar overall risk of recurrence as those with proximal deep vein thrombosis (DVT), according to a study published online in the Journal of Thrombosis and Haemostasis.
Jean-Philippe Galanaud, MD, PhD, from Montpellier University in France, and colleagues used data from a prospective, multicenter study to examine the risk and type of venous thromboembolic (VTE) recurrence at 3 years and after anticoagulants were stopped. Recurrence was assessed for 285 patients with a first objectively confirmed iSVT without cancer and 262 patients with a first proximal DVT without cancer.
The researchers found that iSVT patients had a similar overall incidence of VTE recurrence compared with proximal DVT patients (5.4% vs 6.5% per patient-year; adjusted hazard ratio [aHR]: 0.9; 95% CI, 0.5-1.6), but they had increased risk of iSVT recurrence (2.7% vs 0.6%; aHR: 5.9; 95% CI, 1.3-27.1) and reduced risk of deep-VTE events (2.5% vs 5.9%; aHR: 0.4; 95% CI, 0.2-0.9).
"In patients with a first iSVT without cancer, after stopping anticoagulants, the incidence of deep-VTE recurrence is twice lower than that of proximal DVT patients but overall risk of recurrence is similar," the authors write.
Galanaud J-P, Sevestre M-A, Pernod G, et al. Long-term risk of venous thromboembolism recurrence after isolated superficial vein thrombosis [published online March 20, 2017]. J Thromb Haemost. doi: 10.1111/jth.13679