Pilot Study to Assess Effectiveness of Milrinone in Congenital Diaphragmatic Hernia
Anecdotal evidence suggests milrinone improves oxygenation in pulmonary hypertension associated with congenital diaphragmatic hernia.
Tadalafil, a phosphodiesterase 5 (PDE5) inhibitor, is indicated to treat pulmonary arterial hypertension to improve exercise ability.
FREEDOM-EV was an international, multicenter, randomized, double-blind, placebo-controlled trial (N=690) that randomized patients to 3 daily doses of Orenitram or placebo.
Patients with group 1 pulmonary hypertension who had a higher pulmonary-systemic pulse pressure ratio had a higher risk for mortality.