Endoscopic Sleeve Gastroplasty Promotes Weight Loss, Insulin Sensitivity

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Serious adverse events were seen in 3 patients, but no surgical interventions were required for recovery.
Serious adverse events were seen in 3 patients, but no surgical interventions were required for recovery.

HealthDay News – The minimally invasive procedure endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and successfully results in weight loss, according to a study published in the Clinical Gastroenterology and Hepatology.

Barham K. Abu Dayyeh, MD, MPH, from the Mayo Clinic in Rochester, Minnesota, and colleagues examined the durability and effects of ESG on body weight and gastrointestinal function in a prospective study. Twenty-five obese individuals underwent ESG from September 2012 through March 2015; they were followed for a median of 9 months.

The researchers found that at 6, 9, 12, and 20 months after the procedure, subjects had lost 53% ± 17%, 56% ± 23%, 54% ± 40%, and 45% ± 41% of excess body weight, respectively (P <.01). At 3 months, endoscopy revealed intact gastroplasty in all subjects. Physiological analyses of 4 patients after ESG showed a 59% decrease in caloric consumption to reach maximum fullness (P =.003), slowing of gastric emptying of solids (P =.03), and a trend toward increased insulin sensitivity (P =.06). 

Serious adverse events were observed in 3 patients (perigastric inflammatory collection, pulmonary embolism, and small pneumothorax); they made full recoveries without the need for surgical interventions. After the technique was adjusted there were no further serious adverse events.

"ESG delays gastric emptying, induces early satiation, and significantly reduces body weight," the authors wrote. "ESG could be an alternative to bariatric surgery for selected patients with obesity."

Disclosures: Two authors disclosed financial ties to Apollo Endosurgery, which partially funded the study.

Reference

Dayyeh BKA, Acosta A, Camilleri M, et al. Endoscopic sleeve gastroplasty alters gastric physiology and induces loss of body weight in obese individuals. Clin Gastroenterol Hepatol. 2017;15(1):37-43.e1. doi:10.1016/j.cgh.2015.12.030.

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