Most cases of leukopenia are associated with a low number of granulocytes.
Decreased production of granulocytes may be caused by marrow failure, infiltration of the marrow by leukemic cells or metastatic cancer cells, suppression of granulocyte production by certain drugs, and vitamin B12 or folate deficiency.
There may be an accelerated removal of granulocytes following exposure to certain drugs, as part of an autoimmune disorder, in certain infections, or from splenic sequestration of granulocytes.
Suggested Additional Lab Testing
Most important test: WBC count and differential
Peripheral blood smear and bone marrow aspirate, with or without bone marrow biopsy, is informative in the diagnosis of certain leukopenias.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
The Cardiology Advisor Articles
- AHA/ACC: Updated Management Guidelines for Adult Congenital Heart Disease
- USPSTF Does Not Recommend Afib Screening in Asymptomatic Patients
- American Heart Association Urges Screen Time Limits for Youth
- Patient Connectivity Benefits Familial Chylomicronemia Syndrome
- FDA Approves First Drug Under the Competitive Generic Therapy Pathway
- Apixaban Lowers Bleeding Risk in Afib With End-Stage Kidney Disease
- Tricuspid Regurgitation Velocity Unreliable Indicator of Pulmonary Hypertension
- Supplementing Pulmonary Arterial Hypertension Therapy With Nutritional Changes
- The Challenge of Compassion in Modern Healthcare Settings
- Concomitant NSAID and Anticoagulant Use May Increase Stroke, Bleeding Risk in Afib
- Extreme Preterm Infants at Risk for Early Age High Blood Pressure
- Anemia Identified as Risk Factor for Contrast-Induced Acute Kidney Injury
- Case: Hypertensive Crisis Following Use of Armodafinil + MAOI
- Triple Combination Pill Can Improve Blood Pressure Control
- Labetalol Use Higher in Patients With Preeclampsia and Asthma