Vitamin D as a Means of Cardioprotection in Elective PCI
The researchers recommended larger outcome-based clinical trials to determine if vitamin D can prevent cardiac injury after PCI.
HealthDay News — More research is needed to assess the role of vitamin D in the prevention of periprocedural myocardial injury, according to a study published online in the Journal of Clinical Pharmacology.
Naser Aslanabadi, MD, from Tabriz University of Medical Sciences in Iran, and colleagues randomized 99 patients admitted for elective percutaneous coronary intervention (PCI) into vitamin D (n=52) and control (n=47) groups. Twelve hours before PCI, the intervention group received 300,000 IU vitamin D orally.
The researchers found that 42% of patients in the control group and 34.6% in the intervention group had an increase in creatine kinase-MB (CK-MB) (P =.417). The increase in cardiac troponin I occurred in 8% of patients in the control group and 3.3% in the intervention group (P =.419). There were no significant changes in the level of cardiac biomarkers. The mean difference in CK-MB between 8 and 24 hours was significantly lower in the vitamin D group (P =.048). The vitamin D group also had significantly lower mean difference in high-sensitivity C-reactive protein (P =.045).
"This study could not show a clear effect of vitamin D in the prevention of cardiac injury during elective PCI," the authors wrote. "Based on the results of the present study, larger outcome-based, double-blind, placebo-controlled trials with a longer duration of vitamin D administration to correct the level of vitamin D above 30 ng/mL are recommended to demonstrate a clear effect of vitamin D supplementation in the prevention of cardiac injury following elective PCI."
Aslanabadi N, Jafaripor I, Sadeghi S, et al. Effect of vitamin D in the prevention of myocardial injury following elective percutaneous coronary intervention: a pilot randomized clinical trial [published online August 25, 2017]. J Clin Pharmacol. doi:10.1002/jcph.989