Diabetes Increases Risk of Adverse Outcomes in Heart Failure

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Elevated HbA1c "markedly increased" a patient's risk of experience an adverse outcome 1-year post-admission for heart failure.
Elevated HbA1c "markedly increased" a patient's risk of experience an adverse outcome 1-year post-admission for heart failure.

HealthDay News — For outpatients with chronic heart failure, diabetes is associated with increased risk of one-year adverse outcomes, according to a study published online in Diabetes Care.

Marco Dauriz, MD, from the University and Azienda Ospedaliera Universitaria Integrata of Verona in Italy, and colleagues examined whether diabetes status independently affects the 1-year risk of all-cause and cardiovascular disease (CVD) mortality and first hospitalization for heart failure in a cohort of 9,428 outpatients with chronic heart failure.

The researchers found that patients with diabetes had higher cumulative rates of 1-year all-cause death (9.4% vs 7.2%; adjusted hazard ratio [aHR]: 1.28; 95% CI, 1.07-1.54), CVD death (4.8% vs 3.8%; aHR: 1.28; 95% CI, 0.99-1.66), and heart failure hospitalization (13.8% vs 9.3%; aHR: 1.37; 95% CI, 1.17-1.60), compared with those without diabetes, irrespective of confounding variables. There was a significant and independent association between increasing hemoglobin A1c (HbA1c) level with the risk of 1-year survival outcomes among the 2,567 patients with HbA1c measurements available at baseline.

"The presence of diabetes markedly increases the risk of 1-year adverse clinical outcomes in outpatients with chronic heart failure independent of multiple common risk factors," the authors write. "More effective and personalized treatment for diabetes should be considered in this particularly high-risk patient population."

Several authors disclosed financial ties to the pharmaceutical and medical device industries. Several pharmaceutical companies provided support for the EURObservational Research Program.

Reference

Fauriz M, Targher G, Laroche C, et al. Association between diabetes and 1-year adverse clinical outcomes in a multinational cohort of ambulatory patients with chronic heart failure: results from the ESC-HFA heart failure long-term registry [published online March 2, 2017]. Diabetes Care. doi: 10.2337/dc16-2016

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