Aspirin May Be Safe to Administer in Heart Failure

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Researchers randomly assigned patients with heart failure to either warfarin or aspirin 325 mg/d.
Researchers randomly assigned patients with heart failure to either warfarin or aspirin 325 mg/d.

HealthDay News — Some research has raised concerns about the safety of aspirin for heart failure patients, but a new study, published in JACC: Heart Failure, appears to offer some reassurance.1,2

Shunichi Homma, MD, from the New York-Presbyterian/Columbia University Medical Center in New York City, and colleagues analyzed data from a clinical trial in which patients with heart failure were randomly assigned to take either aspirin or warfarin. Patients in the aspirin group took 325 mg/d.

The study, of 2305 patients, found that those on daily aspirin were not at heightened risk of being hospitalized for, or dying from, heart failure. During the course of 10 years, 19.3% of patients who took aspirin were hospitalized for heart failure, or died of the disease. That compared with 23.2% of patients who took warfarin. Dr Homma's team also accounted for other factors, including patients' age and heart disease severity. In the end, there was no statistical difference between the 2 groups in their risk for heart failure complications.

"Among patients with heart failure with reduced ejection fraction in the WARCEF [Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction] trial, there was no significant difference in risk of heart failure events between the aspirin and warfarin-treated patients," the authors wrote.

Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.

References

  1. Teerlink JR, Quian M, Bello NA, et al. Aspirin does not increase heart failure events in heart failure patients. JACC Heart Fail. 2017. doi:10.1016/j.jchf.2017.04.011
  2. Cleland JGF. What do cardiology and homeopathy have in common? A belief in aspirin? JACC Heart Fail. 2017. doi:10.1016/j.jchf.2017.06.009
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