Risk for All-Cause Mortality in HFrEF With Abdominal Obesity

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The researchers found that 500 patients died during a mean follow-up of 3.4 years.
The researchers found that 500 patients died during a mean follow-up of 3.4 years.

HealthDay News — For patients with heart failure with preserved ejection fraction (HFpEF), abdominal obesity is associated with increased risk for all-cause mortality, according to a study published in the Journal of the American College of Cardiology.

Tetsuro Tsujimoto, MD, PhD, and Hiroshi Kajio, MD, PhD, from the National Center for Global Health and Medicine in Tokyo, and colleagues examined the correlation between abdominal obesity and the risk for all-cause mortality using data from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial. Data were included for 3310 patients with HFpEF: 2413 with abdominal obesity and 897 patients without abdominal obesity.

The researchers found that 500 patients died during a mean follow-up of 3.4 years. 

For patients with and without abdominal obesity, all-cause mortality rates were 46.1 and 40.7 events per 1000 person-years, respectively. The risk for all-cause mortality was significantly higher for patients with vs those without abdominal obesity, after multivariable adjustment (adjusted hazard ratio, 1.52). Patients with vs without abdominal obesity also had significantly higher risk of cardiovascular and non-cardiovascular mortality (adjusted hazard ratios, 1.50 and 1.58, respectively).

"The risk for all-cause mortality was significantly higher in patients with HFpEF with abdominal obesity than in those without abdominal obesity," the authors write.

Reference

Tsujimoto T, Kajio H. Abdominal obesity is associated with an increased risk for all-cause mortality inpatients with HFpEF. J Am Coll Card. 2017,70(22):2739-2749.

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