Genetics

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ARVD/Cardiomyopathy: Interview with Expert Hugh Calkins, MD

ARVD/Cardiomyopathy: Interview with Expert Hugh Calkins, MD

While ARVD/C management has greatly improved, more precautions—particularly in genetic testing and exercise—need to be taken.

Latest News

Gene Editing May Provide New Treatment Option for Hypertrophic Cardiomyopathy

Gene Editing May Provide New Treatment Option for Hypertrophic Cardiomyopathy

Researchers have used a gene-editing tool to repair the segment of DNA that causes hypertrophic cardiomyopathy.

Coronary Artery Disease and Serum Calcium Levels: Is There a Genetic Connection?

Coronary Artery Disease and Serum Calcium Levels: Is There a Genetic Connection?

A genetic predisposition to elevated serum calcium levels may increase the risk for coronary artery disease and myocardial infarction.

Genetic Variants May Explain High Sodium Consumption

Genetic Variants May Explain High Sodium Consumption

Individuals with 1 or 2 dominant G alleles of rs713598 in the TAS2R38 gene were 1.9 times more likely to consume sodium >2.3 g/d.

Fewer Than 2% of Severe Hypercholesterolemia Cases Related to Familial Hypercholesterolemia

Fewer Than 2% of Severe Hypercholesterolemia Cases Related to Familial Hypercholesterolemia

While fewer than 2% of severe hypercholesterolemia cases can be linked to familial hypercholesterolemia mutations, the latter does increase risk for coronary artery disease.

CYP2C19 Gene Not Related to Cardiovascular Outcomes in ACS Patients

CYP2C19 Gene Not Related to Cardiovascular Outcomes in ACS Patients

Genetic testing did not affect decisions regarding the use of clopidogrel or prasugrel in patients with acute coronary syndromes.

ALPK3 Biallelic Mutations Implicated in Pediatric Cardiomyopathy

ALPK3 Biallelic Mutations Implicated in Pediatric Cardiomyopathy

Patients with biallelic mutations in ALPK3 presented with severe hypertrophic and/or dilated cardiomyopathy.

Neurological Anomalies Observed in Infant LQTS Patients May Be Linked to Severe Cardiac Phenotypes

Neurological Anomalies Observed in Infant LQTS Patients May Be Linked to Severe Cardiac Phenotypes

Neurological disorders in perinatal LQTS patients may be caused by neurological phenotypes associated with severe cardiac phenotypes.

Shared Genetic Predisposition Between Peripartum Cardiomyopathy and Idiopathic Dilated Cardiomyopathy

Shared Genetic Predisposition Between Peripartum Cardiomyopathy and Idiopathic Dilated Cardiomyopathy

Peripartum cardiomyopathy shares genetic predisposition, TTN truncating variants, with both idiopathic and familial cardiomyopathy.

Hypocretin/Orexin Receptor-2 May Play a Role in the Treatment of Heart Failure

Hypocretin/Orexin Receptor-2 May Play a Role in the Treatment of Heart Failure

Hypocretin (orexin) receptor-2, a new genetic contribution to heart failure may have promising treatment effects.

New Genes Linked to Development of Coronary Artery Disease

New Genes Linked to Development of Coronary Artery Disease

Ten new genes have been found to be associated with coronary artery disease susceptibility.

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