Genetics

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Pulmonary Arterial Hypertension and Genetics: Interview With the Experts

Pulmonary Arterial Hypertension and Genetics: Interview With the Experts

James E. Loyd, MD, and Wendy Chung, MD, PhD, offer insight into the role of genetics in pulmonary arterial hypertension.

Circulating Extracellular RNAs Tied to Insulin Resistance

Circulating Extracellular RNAs Tied to Insulin Resistance

Across nearly 400 ex-RNAs, 18 were associated with insulin resistance in age-, sex-, and body mass index-adjusted models.

Growth Differentiation Factor 15 May Inform Metformin Dosing

Growth Differentiation Factor 15 May Inform Metformin Dosing

For every one standard deviation increase in GDF15 level, the odds of metformin use varied from 3.73 to 3.94.

Genetic Variants May Explain High Sodium Consumption

Genetic Variants May Explain High Sodium Consumption

Individuals with 1 or 2 dominant G alleles of rs713598 in the TAS2R38 gene were 1.9 times more likely to consume sodium >2.3 g/d.

Systolic Blood Pressure Increase Linked to Diabetes

Systolic Blood Pressure Increase Linked to Diabetes

A 1 mm Hg elevation of systolic blood pressure correlated with a 2% increase in risk of type 2 diabetes.

LDL Cholesterol Lowering Genetic Variants Increase Diabetes Risk

LDL Cholesterol Lowering Genetic Variants Increase Diabetes Risk

Low-density lipoprotein cholesterol-lowering genetic variants were associated with a higher risk of developing type 2 diabetes.

Genetic Variants Predicted CV Effect of Intensive Glycemic Control

Genetic Variants Predicted CV Effect of Intensive Glycemic Control

Researchers identified 2 loci that attained genome-wide significance as determinants of CV mortality in the intensive glycemic treatment arm of ACCORD.

Hypertrophic Cardiomyopathy Variants Misclassified as Pathogenic

Hypertrophic Cardiomyopathy Variants Misclassified as Pathogenic

Multiple patients of African or unspecified ancestry received positive reports, with variants misclassified as pathogenic, but on subsequent re-categorization, all variants were benign.

Two Novel Loci Identified With Insulin Sensitivity

Two Novel Loci Identified With Insulin Sensitivity

The associations at BCL2 and FAM19A2 were independent of known cardiometabolic loci.

ARVD/Cardiomyopathy: Interview with Expert Hugh Calkins, MD

ARVD/Cardiomyopathy: Interview with Expert Hugh Calkins, MD

While ARVD/C management has greatly improved, more precautions—particularly in genetic testing and exercise—need to be taken.

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