Anticoagulation

VKA vs Non-VKA Oral Anticoagulants: Mortality Rates Compared in AF

VKA vs Non-VKA Oral Anticoagulants: Mortality Rates Compared in AF

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The new analysis included 19,134 of these patients and showed that there were 19% fewer deaths in patients initiated on NOACs compared to VKAs at the time of AF diagnosis.

CHEST Releases Guideline for Antithrombotic Therapy in Atrial Fibrillation

CHEST Releases Guideline for Antithrombotic Therapy in Atrial Fibrillation

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Patients with atrial fibrillation who have ≥1 non-sex CHA2DS2VASc stroke risk factor should receive oral anticoagulation as antithrombotic therapy.

Labeling for Several HIV Meds Updated to Include Interaction Data With DOACs

Labeling for Several HIV Meds Updated to Include Interaction Data With DOACs

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If Tybost is given with atazanavir or darunavir, coadministration with rivaroxaban is not recommended due to a potentially increased bleeding risk.

Concomitant NSAID and Anticoagulant Use May Increase Stroke, Bleeding Risk in Afib

Concomitant NSAID and Anticoagulant Use May Increase Stroke, Bleeding Risk in Afib

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Patients with atrial fibrillation who take NSAIDs in addition to oral anticoagulants may have an increased risk for major bleeding and stroke.

Apixaban Lowers Bleeding Risk in Afib With End-Stage Kidney Disease

Apixaban Lowers Bleeding Risk in Afib With End-Stage Kidney Disease

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Apixaban demonstrated superiority over warfarin in terms of reducing the risk for major bleeding in patients with atrial fibrillation and end-stage kidney disease who were on dialysis.

Apixaban Is Safest Direct Oral Anticoagulant vs Warfarin

Apixaban Is Safest Direct Oral Anticoagulant vs Warfarin

Apixaban reduced risks of major, intracranial, and gastrointestinal bleeding compared with warfarin.

Dabigatran May Reduce Major Vascular Complication Risk After Noncardiac Surgery

Dabigatran May Reduce Major Vascular Complication Risk After Noncardiac Surgery

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Dabigatran may be associated with a risk reduction of major vascular complications in patients who develop a myocardial injury after noncardiac surgery.

Gastroprotective Effects of PPIs, H2RAs Compared in Patients on Clopidogrel

Gastroprotective Effects of PPIs, H2RAs Compared in Patients on Clopidogrel

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For this study, researchers searched several large databases (from 1980 to 2016) for randomized, controlled trials (RCTs) that compared clinical outcomes in patients on DAPT taking PPIs or H2RAs.

Troponin-T, NT-proBNP May Predict Mortality Risk in Atrial Fibrillation

Troponin-T, NT-proBNP May Predict Mortality Risk in Atrial Fibrillation

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Troponin-T, N-terminal pro-B-type natriuretic peptide, and growth differentiation factor-15 may offer prognostic utility on mortality and bleeding events in patients with atrial fibrillation who receive anticoagulation.

Pulmonary Embolism AEs Increase With DOAC Doses Against Manufacturer Recs

Pulmonary Embolism AEs Increase With DOAC Doses Against Manufacturer Recs

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Patients treated for acute pulmonary embolism with direct oral anticoagulants at doses against manufacturer recommendations had a higher rate of major bleeding events.

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

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Data from large Phase 3 studies showed that treatment with rivaroxaban was found to be safe and effective in older patients.

Perioperative VTE Prophylaxis Assessment in Post-Pubertal Adolescents

Perioperative VTE Prophylaxis Assessment in Post-Pubertal Adolescents

A decision-making algorithm on venous thromboembolism prophylaxis was developed by the Association of Paediatric Anaesthetists of Great Britain and Ireland.

New Coagulation Monitoring Device Allows for Wireless Reporting of INR Results

New Coagulation Monitoring Device Allows for Wireless Reporting of INR Results

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The system is intended for properly selected trained users ≥22 years of age who have been stabilized on anticoagulation with vitamin K antagonists for ≥6 weeks.

Stroke Risk Highest in Paroxysmal Afib With Greater Burden of Afib

Stroke Risk Highest in Paroxysmal Afib With Greater Burden of Afib

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A greater burden of atrial fibrillation or flutter in patients with paroxysmal atrial fibrillation was associated with a higher risk for stroke when not taking anticoagulants.

Reduced-Dose Anticoagulants Feasible for Extended VTE Treatment

Reduced-Dose Anticoagulants Feasible for Extended VTE Treatment

Reduced doses be as effective as full-dose direct oral anticoagulants for extended-duration venous thromboembolism treatment.

Extended INR Test Intervals Safe for Warfarin-Treated Patients

Extended INR Test Intervals Safe for Warfarin-Treated Patients

Similar number of out-of-range next INR values were seen in patients with and without extended testing interval.

First Generic Alternative for Mephyton Now Available

First Generic Alternative for Mephyton Now Available

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Amneal's generic product is available in a 5mg strength tablet supplied in 100-count bottles.

Andexxa Approved for Reversing Anticoagulant Activity of Rivaroxaban, Apixaban

Andexxa Approved for Reversing Anticoagulant Activity of Rivaroxaban, Apixaban

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Andexxa, a recombinant modified human Factor Xa (FXa) protein, was approved under the FDA's Accelerated Approval pathway.

Anxiety May Increase Stroke, Intracranial Hemorrhage in Atrial Fibrillation

Anxiety May Increase Stroke, Intracranial Hemorrhage in Atrial Fibrillation

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Anxiety may increase the risk for ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation.

Praxbind Gains Full FDA Approval as Pradaxa Reversal Agent

Praxbind Gains Full FDA Approval as Pradaxa Reversal Agent

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Complete reversal was seen within 4 hours in the majority of patients, as measured by ecarin clotting time (ECT 82%) or diluted thrombin time (dTT 99%). In addition, there was a low late of thrombotic events and no new safety events were reported.

Venous Thromboembolism Prevention After Joint Arthroplasty With Rivaroxaban or Aspirin

Venous Thromboembolism Prevention After Joint Arthroplasty With Rivaroxaban or Aspirin

Extended prophylaxis with aspirin does not differ significantly from rivaroxaban for venous thromboembolism prevention in patients who have undergone total hip or knee arthroplasty.

Digital Adherence Devices: Preventing Strokes in Afib One Reminder at a Time

Digital Adherence Devices: Preventing Strokes in Afib One Reminder at a Time

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Using digital adherence devices to improve medication adherence in patients with atrial fibrillation may reduce the rate of ischemic strokes.

Anticoagulants in Elderly With Afib, CKD May Increase Stroke Risk

Anticoagulants in Elderly With Afib, CKD May Increase Stroke Risk

Anticoagulants are associated with increased risk for ischemic stroke and hemorrhage in older patients with chronic kidney disease and a new diagnosis of atrial fibrillation.

A 45-Year-Old Man Presents to the ED With Shortness of Breath, Confusion

A 45-Year-Old Man Presents to the ED With Shortness of Breath, Confusion

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A 45-year-old man presents to the emergency department with some mental confusion and near syncope.

Acute Coronary Syndrome Benefits From Both Antiplatelets and DOACs

Acute Coronary Syndrome Benefits From Both Antiplatelets and DOACs

Treatment with direct oral anticoagulants in addition to antiplatelet therapy appears efficacious for patients with STEMI.

A 35-Year-Old Pregnant Woman Presents With Progressive Dyspnea and Palpitations

A 35-Year-Old Pregnant Woman Presents With Progressive Dyspnea and Palpitations

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A 35-year-old pregnant woman presents to the emergency department with progressive dyspnea and palpitations that have worsened during the last 3 weeks.

Anticoagulation During Cardiopulmonary Bypass: First-Ever Guidelines Released

Anticoagulation During Cardiopulmonary Bypass: First-Ever Guidelines Released

Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass have been developed.

Measuring Cost-Effectiveness of DOACs, Warfarin for Stroke Prevention

Measuring Cost-Effectiveness of DOACs, Warfarin for Stroke Prevention

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Cost-effective DOACs like apixaban prevent strokes better than warfarin in patients with atrial fibrillation.

Bleeding Risk, Stroke Outcomes With Edoxaban vs Enoxaparin-Warfarin for Cardioversion of Atrial Fibrillation

Bleeding Risk, Stroke Outcomes With Edoxaban vs Enoxaparin-Warfarin for Cardioversion of Atrial Fibrillation

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In patients with atrial fibrillation at high risk for stroke, edoxaban is associated with lower rates of cardiovascular death events.

Triple Therapy in Coronary Artery Disease With GI Bleeding May Increase Mortality Risk

Triple Therapy in Coronary Artery Disease With GI Bleeding May Increase Mortality Risk

Triple therapy is associated with increased mortality risk in patients with LGIB and CAD.

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